To resolve this, initiate a full page postback trigger on update panel:
<asp:UpdatePanel runat="server">
<Triggers>
<asp:PostBackTrigger ControlID="YourControlID" />
</Triggers>
<ContentTemplate>
.....
<asp:UpdatePanel runat="server">
<Triggers>
<asp:PostBackTrigger ControlID="YourControlID" />
</Triggers>
<ContentTemplate>
.....